Not long ago, OFweek 3D Printing Network reported that the US Food and Drug Administration (FDA) first passed a news on drugs produced using 3D printing technology . In recent years, 3D bio-printing technology has been highly sought after, bringing many people to the gospel.
Yan Maling, deputy researcher of the State Key Laboratory of Biotherapy, West China Hospital, Sichuan University, has been using nanotechnology and 3D printing technology since July 2010 to study the basis and transformation of diseases such as tumors. In an interview, he explained: "The advantage of 3D printing technology lies in the individualized preparation of complex structures. Personalized customization of dosage, appearance, taste, etc. can be realized. At the same time, 3D printed 'pills' can have a special microstructure, which helps Improves drug release behavior, thereby improving efficacy and reducing side effects."
Dr. Mohamed Albod Alhan, a lecturer in pharmacy at the University of Central Lancashire, told the media: â€œIn the past 50 years, we have been manufacturing pills at the factory and then sending them to the hospital. This is the first time that 3D has been adopted. Printing methods make pills, which means we can make products that are more suitable for patients."
Alhan explained that medical institutions only need to use software to fine-tune the dose of drugs in 3D printing, so that different patients can print drugs that meet their needs. Prior to this, personal custom drugs were quite expensive.
"However, 3D printing is not suitable for mass production of drugs, and the cost is relatively high." Yan Maling added, but there is no denying that 3D printing drugs have broad needs and application prospects in the future. â€œFor example, 3D printing has a personalized shape or taste to help solve the problem of anti-drugs in children or mental patients; 3D printing technology can be used to develop new slow-release preparations or new compound preparations; 3D printing technology helps to accurately control The dose of low-dose drugs, etc."
3D bioprinting is sought after
The 3D printing tablet technology works by creating a product using a layer-by-layer printing method. When printing a drug, the printer produces a pharmaceutical compound rather than a common polymer.
There is no dispute that 3D printing technology for drug research and development is currently a hot research topic in the world. In an interview, Yan Maling told reporters that 3D printing technology can be used in all aspects of drug research and development, and is expected to lead new breakthroughs in the research and development of new drugs.
"In recent years, 3D printing drugs have received international attention, and a series of basic and translational studies have been carried out around 3D printing drugs, but most of the research is in the preclinical research stage. The lack of personalized 3D printing system is limited to 3D printing drugs. An important factor in development."
Speaking of the development of domestic 3D bio-printing, Yan Maling told reporters that China is one of the first countries to carry out research on 3D bio-printing technology. Many units are carrying out the research and transformation of 3D bio-printing, and established the China Biomaterials Society. 3D printing branch of biomedical materials, a batch of 3D printing products are in the pre-clinical research stage.
"China also attaches great importance to the research of 3D printing drugs, but there is still a big gap compared with developed countries such as the United States, especially in the basic principles, key technologies and major equipment research needs to be strengthened."
Globally, 3D printing technology has been widely recognized in the healthcare field, and many doctors use this technology to tailor implants suitable for their injured patients. Aprecia said that Spritam will be available in the first quarter of 2016. In fact, before passing 3D printing drugs, the FDA has approved 3D printing technology for some medical devices including prosthetics.
"China has independently developed a batch of 3D bio-printing systems and 3D bio-printing materials, and has accumulated rich experience in 3D printing technology for medical device research and development, new drug research and development, and living organ construction, in order to promote 3D printing technology into clinical practice. The application provides a good support. However, 3D printing of living organ research still faces many problems, and there is still a long distance from clinical application, which needs further study.â€ Yan Maling said, but internationally, â€œ The 3D printed miniature liver for early drug evaluation has been commercialized in the United States and other places."
Taking the State Key Laboratory of Biotherapy of West China Hospital of Sichuan University where Huo Maling is located as an example, the laboratory is developing 3D printing technology for the research and development of new drugs. Has independently developed a new type of 3D printer and a variety of 3D printing hydrogel materials, and combined 3D printing technology with nanotechnology, explored 3D printing technology in drug discovery, drug screening, pharmaceutical preparations, drug evaluation, etc. In terms of potential applications, a variety of new drug candidates for diseases such as malignant tumors are being developed in preclinical research.
The FDA approved the listing of Spritam. In the view of Yan Maling, this not only marks the official entry of 3D printing drugs into clinical applications, but also proves the important value of 3D printing technology in drug development.
"Provides demonstrations for more 3D printing drugs, which provides reference for China's approval and supervision of 3D printing drugs into clinical applications, and has encouraged scientists and entrepreneurs in related fields to be of great significance in promoting the development of 3D printing drugs."
According to reports, from the current domestic situation, there is no officially approved 3D printing products for clinical use, and relevant laws and regulations need to be established and improved as soon as possible. At the same time, a number of key technologies for 3D printing technology in the clinical medical field need to be further broken to ensure the effectiveness and safety of 3D printing products.
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