Immune prevention should be based on the monitoring of epidemic diseases, the prevalence of epidemics, combined with the local animal epidemic situation and the nature and role of vaccines, and develop scientific and reasonable immunization procedures in line with the actual situation, and implement immunization in a planned manner. Don't use the vaccine blindly. Don't think of vaccination as omnipotent. Excessive types of vaccination, frequent vaccination, and long-term vaccination with large doses may cause immune paralysis or immunodeficiency in the pigs, and the vaccines may interfere with each other, leading to immune failure. Vaccination reference procedure 1, swine fever, swine spleen spleen vaccine (rabbit source) piglets: 23-28 days of first exemption, 1 injection per head; 65-70 days old 2 exempt, 2 heads per head Share. Reserve pigs: boost the immunization once every 10 days before estrus breeding, 2 servings per head. Production of sows: 1 booster 10 days after birth, 2 heads per head. Boars: 1 immunization per spring and autumn, 2 injections per muscle each time. Attenuated swine fever vaccine is not given during pregnancy. Because the big white rabbit can not meet the needs of spleen vaccination production, a few manufacturers have mixed cell vaccine with contaminated mucosal virus in pig spleen and spleen seedlings. In 2009, China Veterinary Drug Surveillance Institute used 22 ELISA methods to check 22 batches of spleen and spleen seedlings. Among them, 5 batches were contaminated with contaminated attenuated cell seedlings. 2, swine fever attenuated live vaccine (bovine testicular cell vaccine) immunization program is the same as pig sputum spleen seedlings. China's herd infection with mucosal disease virus (BVDV) is almost 100%, and negative cattle are rarely detected. The use of bovine testicular cells to produce swine fever vaccine is very likely to cause BVDV contamination. Vaccination of pigs with contaminated cell seedlings can not only interfere with the production of antibodies against swine fever vaccine, but also cause immune failure; and BVDV can also cause reproductive failure in sows, viruses. Passing through the placenta to piglets, causing the incidence of piglets, the incidence rate is as high as 50%, its clinical symptoms and pathological changes are very similar to piglets, identification and detection is very difficult. In 2009, the Chinese veterinary drug monitoring institute used 23 PCR methods to detect 23 batches of pig yak testicular cell vaccine. It was found that there were 5 batches of vaccine contaminated with BVDV, and the contamination rate was 21.74%. Many pig farms use piglet cell vaccine to immunize pigs, and piglets still occur, causing significant economic losses. 3. The immunization program of ST piglet passage cell live vaccine is the same as that of pig spleen spleen seedling, which is characterized by high virus titer, stable production process, easy quality control, small difference between batches, high immunity, safe and effective effect; Exogenous virus contamination reduces the interference of mixed infections of other viruses. 4, blue ear disease immune blue ear disease attenuated live vaccine piglets: 14 days old first exemption, 1 injection per head; 2 weeks after 2 exemption, 1 per head. Reserve pigs: 1 booster 3 weeks before the first estrus and 2 heads per muscle. Production of breeding pigs: immunization once every four months, each time 15 days before breeding, 2 injections per muscle. Pregnant sows are not allowed to be inoculated with attenuated live vaccines of blue ear disease. The blue ear disease inactivated vaccine has low protection, long antibody production, poor immune effect, and is not used as much as possible. Attention in immunization: Attenuated live vaccine of blue ear disease can interfere with the production of antibodies by the swine fever vaccine and affect the immune effect of the swine fever vaccine. Two live vaccines cannot be vaccinated at the same time, and should be inoculated separately at intervals of 5-7 days to avoid interference. At the same time, the attenuated vaccine of the blue ear disease is also interfered by the circovirus. When there is a recessive infection of the circovirus in the herd, the attenuated vaccine of the blue ear disease is also affected, and its immune effect is also affected.
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